Emetrol (domperidone) for gastrointestinal problems
Prokinetics are drugs that stimulate gastrointestinal motility. They play a key role in the complex treatment of gastrointestinal pathology. Prokinetics, namely Emetrol quickly relieve clinical manifestations of disorders of motor and evacuatory functions of the stomach, intestines and esophagus. They reduce the terms of the course of diseases of the digestive organs, and thus improve the patient’s well-being and quality of life.
The combination of such common symptoms as pain, burning and congestion, heaviness in the epigastric region, early satiety and discomfort in the epigastric zone, associated or not associated with food intake, belching, heartburn, nausea, vomiting and other unpleasant sensations in this area, and not related to organic pathology of the gastrointestinal tract, are called “functional dyspepsia”. This is the most common pathological condition, which is noted in 12-54% of the population of developed countries, and in 4-10% of cases it is the cause of visits to the therapist.
Emetrol (domperidone) is used to eliminate spasm of the lower esophageal sphincter and pylorus of the stomach, increase the duration of antral and duodenal contractions, increase duodenal peristalsis,
stimulation of gastric motility function, acceleration of gastric emptying, increase of lower esophageal sphincter pressure, normalization of gastroduodenal coordination.
Prokinetics – blockers of dopamine and serotonin receptors, are used in complex treatment of esophageal achalasia, gastroesophageal reflux disease, diabetic gastroparesis, biliary dyskinesia, flatulence, postoperative intestinal paresis, functional dyspepsia, ulcers (of stomach and duodenum). Prokinetics of this group are used for nausea and vomiting resulting from craniocerebral trauma, myocardial infarction, general anesthesia, radiation therapy, liver and kidney diseases, errors in the diet, early toxemia in pregnant women and for prevention of vomiting during endoscopic and X-ray contrast studies.
The indications for the use of emetrol are numerous manifestations of gastrointestinal dysfunction. It is prescribed to reduce the severity of discomfort and heartburn that occur after a meal, to eliminate the feeling of overfilling of the stomach and bloating in the epigastrium, nausea and belching. Emetrol is also indicated to relieve nausea and vomiting that last less than 48 hours.
By blocking dopamine receptors, domperidone enhances motor and evacuatory activity of both esophagus and stomach, activates lower esophageal sphincter tone, positively influencing esophageal clearance. The effects of domperidone are realized in the form of increased duration of contraction of the antral part of the stomach (gateway cave) and contraction of the duodenum. The maximum concentration is reached already in 1 h, and the half-life of domperidone is within 7-8 h. It is believed that the antiemetic effect of domperidone is due to its blockade of dopamine chemoreceptors of the trigger zone and peripheral gastrokinetic action. The peculiarity of domperidone is multidirectionality of its action, depending on the variant of motor dysfunction. In case of impaired peristalsis domperidone increases gastric tone and normalizes its peristalsis, and in case of contractile hyperactivity of gastric wall – reduces its tone. Domperidone combines well with proton pump inhibitors.
The drug practically does not penetrate through the blood-brain barrier, although in children during the first three months of life the blood-brain barrier due to its incomplete maturity may be permeable for the drugs, including domperidone. At the same time, there is information about normalization of defecation with domperidone in constipation in children.